Klinefelter's+Syndrome

Klinefelter's Syndrome Klinefelter's Syndrome is a genetic disorder in which a male has an extra X chromosome. It is also sometimes referred to as 47, XXY or XXY syndrome.

Klinefelter's is actually one of the few genetic disorders that is not inherited. It occurs at random during the creation of sex cells and is a form of nondisjunction. Normally, people have two sex chromosomes in each of their cells. A male has one X and one Y chromosome (XY), and a female has two X chromosomes (XX). Klinefelter's Syndrome is most commonly the product of one extra X chromosome in each of a males sex cells.

(Below is a karotype for a normal person without a genetic disorder) (Below is a karotype of a male who has Klinefelter's Syndrome)
 * **Male: 46 XY** ||
 * [[image:http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/library.thinkquest.org/18258/media/46XY.gif width="422" height="313" caption="Male Karyotype: 46 XY"]] ||
 * **Klinefelter's Syndrome: 47 XXY** ||
 * [[image:http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/library.thinkquest.org/18258/media/47XXY.gif width="423" height="298" caption="Kleinfelter's Syndrome: 47XXY"]] ||

Klinefelter's syndrome is a chromosomal disorder that gives males an extra X chromosome, which causes malfunctions in sexual development. Males with Klinefelter's typically have small testes and do not produce a sufficient amount of testosterone. This shortage can lead to abnormal breast growth, reduced body and facial hair, smaller muscles, and infertility. Older children and adults with Klinefelter's Syndrome tend to be taller than that of other males their age. Adult males with this disorder have a greater risk of developing breast cancer than other males without Klinefelter's. However, as males with Klinefelter's syndrome grow to adults they look similar to males without the disorder. Some variants of this disorder leave a male with more than one extra X chromosome. This causes the affected people to have more serious symptoms such as i ntellectual disability, distinctive facial features, skeletal abnormalities, poor coordination, and severe problems with speech . 

Klinefelter's is normally not discovered until puberty. When puberty is supposed to occur the male develops enlarged breasts and does not grow as much body and facial hair, then the doctor must make a karotype so they can see if he has two X chromosomes or one X chromosome. This disease could be discovered at birth if they had a karotype, but normally it is not diagnosed until the symptoms appear.

SOURCES [|http://ghr.nlm.nih.gov/condition=klinefeltersyndrome] [|http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/library.thinkquest.org/18258/noframes/ped-karyo2.htm] [|http://www.mamashealth.com/syndrome/Kleinfeltr.asp] [] __h__ [|ttp://www.andrologyaustralia.org/images/pageContentImages/KlinefeltersIMG.jpg]

[[http://www.peacehealth.org/kbase/topic/mini/hw183686/overview.htm|http://www.peacehealth.org/kbase/topic/mini/hw183686/overview.htm

]]Daniel Adams